The measurement of isolated tissue contractility is widely used in preclinical research.
In vitro contractility assay can be conduct on various types of tissue, such as aortic rings, trachea, papillary muscle, uterine tissue, ileum or colon, during drug exposure and/or electrical stimulation.
Tissue is hanged by a pair of hooks and immersed into a tube shaped bath. The bath is filled with a heated perfusate, providing oxygen and nutrient to the tissues to ensure its viability while data are acquired.
Solution may be renewed by overflow-suction, so tissue is never exposed to air.
The force of muscular contraction is transmitted along the hook to the transducer.Tissue tension is adjustable and can be controlled from the mainframe control panel or from the acquisition software.
Advantages of the technique: